Dr. Valentin Fuster discusses the body's three natural defense mechanism against cardiovascular disease. First, he describes progenitor endothelial cells produced by the bone marrow help protect coronary artery disease and the prospects of how pharmacologically we may help support the body in this defense mechanism. Secondly, he describes how blood gradient concentration with the help of statins extracts cholesterol from the coronary arteries. Finally, he describes how HDL or good cholesterol helps keep the coronary arteries clear of LDL or bad cholesterol. Dr. Valentin Fuster is the former Presidents of the World Heart Federation and The American Heart Association. Dr. Fuster also serves Director of both The Zena and Michael A. Wiener Cardiovascular Institute and The Marie-Josée and Henry R. Kravis Center for Cardiovascular Health at Mount Sinai Hospital in New York City.